Low-Dose Naltrexone for Weight Loss: A New Addition to Your GLP-1 Journey

Losing weight has never been easier! If you’re ready to transform your body and become the best version of yourself, 2025 might just be your year. Why? Because science is revolutionizing weight loss like never before.

While diet and exercise have always been instrumental in shedding pounds, we now understand that weight loss is more than just calorie counting—it’s about metabolism, hormones, cravings, and overall health. GLP-1 drugs like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have changed the game thanks to groundbreaking advancements in weight loss medications. However, some struggle with appetite control, metabolic resistance, or stubborn fat loss. That’s where low-dose naltrexone (LDN) comes in.

At ZYP Medical, we are always looking for the latest medical advancements to help our patients achieve long-term weight loss success. We’re excited to introduce LDN as a complementary drug to GLP-1 treatments. It offers enhanced appetite control, metabolic support, and reduced inflammation. Could LDN accelerate your weight loss journey?

In this blog, we’ll explore how naltrexone works, who it benefits most, and whether you should take it.

What is Low-Dose Naltrexone (LDN)?

Naltrexone was originally developed in the 1980s as an FDA-approved treatment for opioid and alcohol addiction. At full doses (50 mg+), it blocks opioid receptors, preventing the euphoric effects of opioids and alcohol.

However, later on, researchers discovered that naltrexone had utterly different effects when used in much lower doses (1 to 5 mg). It helps regulate the immune system, reduce inflammation, and improve metabolic function.

Since then, LDN has been studied for a variety of health benefits, particularly in treating: 

• Chronic pain conditions (fibromyalgia, arthritis) 

• Autoimmune disorders (Hashimoto’s thyroiditis, multiple sclerosis) 

• Mood disorders (depression, anxiety) 

• Digestive conditions (IBS, Crohn’s disease)

Most recently, researchers and physicians have started exploring “what is low dose naltrexone” and its impact on metabolism and weight loss—and the results are promising.

How Low-Dose Naltrexone Supports Weight Loss

LDN does not work like a traditional weight loss drug—it doesn’t suppress appetite instantly like stimulants or induce weight loss through artificial means. Instead, it rebalances the body’s natural regulatory systems, making it easier to control cravings, burn fat efficiently, and maintain a healthy metabolism.

1. Reduces Cravings & Appetite

Food cravings are often driven by dopamine imbalances—the same neurochemicals involved in addiction. LDN modulates dopamine and endorphin levels, making food less “rewarding” and easier to control.

• It helps curb sugar and carb cravings, reducing emotional and binge eating.

• Supports appetite regulation by balancing hunger hormones.

• Improves adherence to healthy eating habits, essential for long-term weight management.

This means if you often snack late at night or crave sugary treats, LDN may help you gradually diminish those urges.

 2. Enhances Metabolism & Fat Burning

LDN does not directly burn fat but optimizes metabolic processes impacting weight regulation. It works by:

• Increasing beta-endorphins, which support a higher metabolic rate.

• Regulating insulin sensitivity helps stabilize blood sugar and prevent weight gain.

3. Decreases Inflammation & Supports Hormonal Balance

Chronic inflammation is one of the biggest roadblocks to successful weight loss. When the body is constantly inflammatory, it stores fat more efficiently and burns fewer calories. LDN has anti-inflammatory effects, helping to:

• Lower C-reactive protein (CRP) levels are a key marker of inflammation. 

• Support immune system regulation, reducing inflammation-driven weight gain.

Because of its multi-system effects, LDN offers additional benefits beyond weight loss, including chronic pain relief, mood and mental health support, and gut health support. 

Potential Side Effects & Considerations

While low-dose naltrexone side effects are minimal for most users, some may experience mild symptoms, including: 

• Mild nausea or headaches – Usually temporary and improve over time. 

• Sleep disturbances & vivid dreams – Some patients report intense dreaming, which typically resolves.

• Opioid medication interactions – If you are currently on opioid therapy, LDN is not recommended to you.

What to avoid when taking low-dose naltrexone? 

• Avoid opioid pain medications while taking LDN.

• Speak with a doctor before combining LDN with immunosuppressants.

Apart from the side effects mentioned above, low-dose naltrexone (LDN) may not be suitable for everyone. Specific individuals may face additional risks, which we briefly discuss in the next section. 

Is Low-Dose Naltrexone Right for You?

LDN may be an excellent addition to your GLP-1 weight loss regimen, but it’s not for everyone. Consider LDN if you: 

• Struggle with food cravings and emotional eating.

• Have metabolic resistance, PCOS, or insulin issues.

• Experience chronic pain or inflammation that makes weight loss harder.

• Want a comprehensive approach that supports overall health and well-being.

However, LDN is NOT recommended if you: 

• Are currently taking opioid medications. 

• Are pregnant or breastfeeding.

• Have severe liver or kidney disease (consult a doctor first).

In essence, the long-term side effects of low-dose naltrexone are still being studied, but current research suggests that LDN remains safe and well-tolerated over time. At ZYP Medical, we believe in personalized, science-backed weight loss solutions. If GLP-1 medications alone haven’t given you the desired results, adding LDN may be the missing piece to help you control cravings, improve metabolism, and achieve sustainable weight loss.

Accelerate Your Weight Loss Journey with Low-Dose Naltrexone by ZYP Medical

ZYP Medical offers the most affordable weight loss programs to help you achieve sustainable weight management, better health, and an enhanced quality of life. Our dedicated team provides expert guidance and personalized Semaglutide/Tirzepatide dosages to support your weight loss journey at a price that fits your budget.

Why Choose Us?

• Personalized Weight Loss Strategies: We customize each plan to fit your health goals and lifestyle, ensuring results that meet your unique needs.

• Access to Semaglutide and Tirzepatide: We provide adequate medical support for weight loss.

• Expert Medical Supervision: Your weight-loss journey is guided by qualified physicians who monitor every aspect of your treatment for safety and optimized results.

• Comprehensive Wellness Support: From nutritional guidance to lifestyle adjustments, our approach ensures you have expert advice and support at each stage.

With ZYP Medical, you experience the utmost care & convenience of personalized medical care.

Let’s get you in shape! Book a consultation now.